Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy

AIMS/HYPOTHESIS: The glucosuria induced by sodium–glucose cotransporter 2 (SGLT2) inhibition stimulates endogenous (hepatic) glucose production (EGP), blunting the decline in HbA(1c). We hypothesised that, in response to glucosuria, a renal signal is generated and stimulates EGP. To examine the effe...

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Publié dans:Diabetologia
Auteurs principaux: Daniele, Giuseppe, Solis-Herrera, Carolina, Dardano, Angela, Mari, Andrea, Tura, Andrea, Giusti, Laura, Kurumthodathu, Jancy J., Campi, Beatrice, Saba, Alessandro, Bianchi, Anna Maria, Tregnaghi, Carla, Egidi, Maria Francesca, Abdul-Ghani, Muhammad, DeFronzo, Ralph, Del Prato, Stefano
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527374/
https://ncbi.nlm.nih.gov/pubmed/32827269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-020-05254-w
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