Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures

Mutations in BRCA1 and BRCA2 cause deficiencies in homologous recombination repair (HR), resulting in repair of DNA double-strand breaks by the alternative non-homologous end-joining pathway, which is more error prone. HR deficiency of breast tumors is important because it is associated with better...

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Publicat a:PLoS One
Autors principals: Bodily, Weston R., Shirts, Brian H., Walsh, Tom, Gulsuner, Suleyman, King, Mary-Claire, Parker, Alyssa, Roosan, Moom, Piccolo, Stephen R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526916/
https://ncbi.nlm.nih.gov/pubmed/32997669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239197
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