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Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women

IMPORTANCE: Among Ashkenazi Jewish women, 3 mutations in BRCA1 and BRCA2 severely increase the risk of breast and ovarian cancer. However, among Ashkenazi Jewish patients with breast cancer who do not carry one of these founder mutations, the likelihood of carrying another pathogenic mutation in BRC...

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Bibliografiske detaljer
Udgivet i:JAMA Oncol
Main Authors: Walsh, Tom, Mandell, Jessica B., Norquist, Barbara M., Casadei, Silvia, Gulsuner, Suleyman, Lee, Ming K., King, Mary-Claire
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824270/
https://ncbi.nlm.nih.gov/pubmed/28727877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.1996
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