Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data

Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological inf...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Kim, Hyeon-Jin, Yardımcı, Galip Gürkan, Bonora, Giancarlo, Ramani, Vijay, Liu, Jie, Qiu, Ruolan, Lee, Choli, Hesson, Jennifer, Ware, Carol B., Shendure, Jay, Duan, Zhijun, Noble, William Stafford
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526900/
https://ncbi.nlm.nih.gov/pubmed/32946435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008173
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