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In Vitro Activity of Manogepix (APX001A) and Comparators against Contemporary Molds: MEC Comparison and Preliminary Experience with Colorimetric MIC Determination

Manogepix (APX001A) is the active moiety of the drug candidate fosmanogepix (APX001), currently in clinical development for the treatment of invasive fungal infections. We compared manogepix EUCAST minimum effective concentrations (MECs) to MICs of five comparators and CLSI MECs and MICs by a colori...

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Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Jørgensen, Karin Meinike, Astvad, Karen M. T., Arendrup, Maiken Cavling
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526828/
https://ncbi.nlm.nih.gov/pubmed/32513793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00730-20
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