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Manogepix (APX001A) Displays Potent In Vitro Activity against Human Pathogenic Yeast, but with an Unexpected Correlation to Fluconazole MICs

Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here, we extended this study and included isolates with acquir...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Arendrup, Maiken Cavling, Jørgensen, Karin Meinike
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318001/
https://ncbi.nlm.nih.gov/pubmed/32366708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00429-20
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