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Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae

Colistin resistance in Klebsiella pneumoniae is predominantly caused by mutations that increase expression of the arn (also known as pbg or pmrF) operon. Expression is activated by the PhoPQ and PmrAB two-component systems. Constitutive PhoPQ activation occurs directly by mutation or following loss...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Cheung, Ching Hei Phoebe, Dulyayangkul, Punyawee, Heesom, Kate J., Avison, Matthew B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526815/
https://ncbi.nlm.nih.gov/pubmed/32457105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00790-20
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