Mutation of kvrA Causes OmpK35 and OmpK36 Porin Downregulation and Reduced Meropenem-Vaborbactam Susceptibility in KPC-Producing Klebsiella pneumoniae

Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pneumoniae isolates. The proteins lost were NlpD and...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Dulyayangkul, Punyawee, Wan Nur Ismah, Wan Ahmad Kamil, Douglas, Edward J. A., Avison, Matthew B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318013/
https://ncbi.nlm.nih.gov/pubmed/32312773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02208-19
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