Open-Label Crossover Oral Bioequivalence Pharmacokinetics Comparison for a 3-Day Loading Dose Regimen and 15-Day Steady-State Administration of SUBA-Itraconazole and Conventional Itraconazole Capsules in Healthy Adults

Super bioavailability (SUBA) itraconazole (S-ITZ), which releases drug in the duodenum, and conventional itraconazole (C-ITZ), which releases drug in the stomach, were compared in two pharmacokinetic (PK) studies: a 3-day loading dose study and a 15-day steady-state administration study. These were...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Thompson, George R., Lewis, Phoebe, Mudge, Stuart, Patterson, Thomas F., Burnett, Bruce P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526808/
https://ncbi.nlm.nih.gov/pubmed/32457106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00400-20
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