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Evidence for Modulatory Sites at the Lipid-Protein Interface of the Human Multidrug Transporter P-Glycoprotein
The human multidrug transporter P-glycoprotein (Pgp or ABCB1) sets up pharmacological barriers to many clinically important drugs, a therapeutic remedy for which has yet to be formulated. For the rational design of mechanism-based inhibitors (or modulators), it is necessary to map the potential site...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7526750/ https://ncbi.nlm.nih.gov/pubmed/22360349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201479k |
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