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Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

The mechanism of inhibition of HIV-1 reverse transcriptase by three nonnucleoside inhibitors is described. Nevirapine, O-TIBO, and Cl-TIBO each bind to a hydrophobic pocket in the enzyme-DNA complex close to the active site catalytic residues. Pre-steady-state kinetic analysis was used to establish...

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Dettagli Bibliografici
Pubblicato in:Science
Autori principali: Spence, Rebecca A., Kati, Warren M., Anderson, Karen S., Johnson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526747/
https://ncbi.nlm.nih.gov/pubmed/7532321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.7532321
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