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Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive
Sympathetically mediated contractions of smooth muscle cells in the vasa deferentia are mediated by neuronally released adenosine 5′-triphosphate (ATP) and noradrenaline, which stimulate P2X1-purinoceptors and α(1A)-adrenoceptors, respectively. This process is crucial for sperm transport, as demonst...
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| Publicado no: | Biol Reprod |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7526726/ https://ncbi.nlm.nih.gov/pubmed/32648904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa117 |
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