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Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive

Sympathetically mediated contractions of smooth muscle cells in the vasa deferentia are mediated by neuronally released adenosine 5′-triphosphate (ATP) and noradrenaline, which stimulate P2X1-purinoceptors and α(1A)-adrenoceptors, respectively. This process is crucial for sperm transport, as demonst...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biol Reprod
मुख्य लेखकों: Mathiew, Mitch, Dennis, Belinda M, Bennetts, Felix, Su, N N Eunice, Nguyen, Nghi, Botteon, Antony, Baell, Jonathan B, Ventura, Sabatino
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526726/
https://ncbi.nlm.nih.gov/pubmed/32648904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa117
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