ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that the NUPR1 inhibitor ZZW-...

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發表在:JCI Insight
Main Authors: Lan, Wenjun, Santofimia-Castaño, Patricia, Swayden, Mirna, Xia, Yi, Zhou, Zhengwei, Audebert, Stephane, Camoin, Luc, Huang, Can, Peng, Ling, Jiménez-Alesanco, Ana, Velázquez-Campoy, Adrián, Abián, Olga, Lomberk, Gwen, Urrutia, Raul, Rizzuti, Bruno, Geli, Vincent, Soubeyran, Philippe, Neira, José L., Iovanna, Juan
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526551/
https://ncbi.nlm.nih.gov/pubmed/32780723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138117
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