ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that the NUPR1 inhibitor ZZW-...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lan, Wenjun, Santofimia-Castaño, Patricia, Swayden, Mirna, Xia, Yi, Zhou, Zhengwei, Audebert, Stephane, Camoin, Luc, Huang, Can, Peng, Ling, Jiménez-Alesanco, Ana, Velázquez-Campoy, Adrián, Abián, Olga, Lomberk, Gwen, Urrutia, Raul, Rizzuti, Bruno, Geli, Vincent, Soubeyran, Philippe, Neira, José L., Iovanna, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526551/
https://ncbi.nlm.nih.gov/pubmed/32780723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138117
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