Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs,...

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Publicado no:Mol Cell Oncol
Main Authors: Santofimia-Castaño, Patricia, Rizzuti, Bruno, Xia, Yi, Abian, Olga, Peng, Ling, Velázquez-Campoy, Adrián, Iovanna, Juan L., Neira, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736491/
https://ncbi.nlm.nih.gov/pubmed/31528692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1612678
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