Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug development targeting IDPs is challenging because IDPs have dynamic structure features and conventional drug design is not applicable. NUPR1 is an...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Santofimia-Castaño, Patricia, Xia, Yi, Lan, Wenjun, Zhou, Zhengwei, Huang, Can, Peng, Ling, Soubeyran, Philippe, Velázquez-Campoy, Adrián, Abián, Olga, Rizzuti, Bruno, Neira, José L., Iovanna, Juan
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546470/
https://ncbi.nlm.nih.gov/pubmed/30920390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127223
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