Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes

Fibroblast-like synoviocytes (FLSs) are critical to joint inflammation and destruction in rheumatoid arthritis (RA). Increased glycolysis in RA FLSs contributes to persistent joint damage. SUMOylation, a posttranslational modification of proteins, plays an important role in initiation and developmen...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wang, Cuicui, Xiao, Youjun, Lao, Minxi, Wang, Jingnan, Xu, Siqi, Li, Ruiru, Xu, Xuanxian, Kuang, Yu, Shi, Maohua, Zou, Yaoyao, Wang, Qingwen, Liang, Liuqin, Zheng, Song Guo, Xu, Hanshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526534/
https://ncbi.nlm.nih.gov/pubmed/32938830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135935
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