Inhibition of 6‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐mediated synovial inflammation and joint destruction in rheumatoid arthritis

BACKGROUND AND PURPOSE: Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls the glycolytic rate, in r...

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Publicado en:Br J Pharmacol
Autores principales: Zou, Yaoyao, Zeng, Shan, Huang, Mingcheng, Qiu, Qian, Xiao, Youjun, Shi, Maohua, Zhan, Zhongping, Liang, Liuqin, Yang, Xiuyan, Xu, Hanshi
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386999/
https://ncbi.nlm.nih.gov/pubmed/28239846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13762
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