Role of in silico structural modeling in predicting immunogenic neoepitopes for cancer vaccine development

In prior studies, we delineated the landscape of neoantigens arising from nonsynonymous point mutations in a murine pancreatic cancer model, Panc02. We developed a peptide vaccine by targeting neoantigens predicted using a pipeline that incorporates the MHC binding algorithm NetMHC. The vaccine, whe...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :JCI Insight
Главные авторы: Zaidi, Neeha, Soban, Mariya, Chen, Fangluo, Kinkead, Heather, Mathew, Jocelyn, Yarchoan, Mark, Armstrong, Todd D., Haider, Shozeb, Jaffee, Elizabeth M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2020
Предметы:
Technical Advance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526456/
https://ncbi.nlm.nih.gov/pubmed/32879142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136991
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы