Role of in silico structural modeling in predicting immunogenic neoepitopes for cancer vaccine development

In prior studies, we delineated the landscape of neoantigens arising from nonsynonymous point mutations in a murine pancreatic cancer model, Panc02. We developed a peptide vaccine by targeting neoantigens predicted using a pipeline that incorporates the MHC binding algorithm NetMHC. The vaccine, whe...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Zaidi, Neeha, Soban, Mariya, Chen, Fangluo, Kinkead, Heather, Mathew, Jocelyn, Yarchoan, Mark, Armstrong, Todd D., Haider, Shozeb, Jaffee, Elizabeth M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Technical Advance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526456/
https://ncbi.nlm.nih.gov/pubmed/32879142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136991
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