Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

Brain senescence is associated with impaired endothelial barrier function, angiogenic and inflammatory activity, and propensity to brain hemorrhage. The same pathological changes occur in cerebral cavernous malformations (CCM), a genetic neurovascular anomaly. We hypothesized common transcriptomic a...

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Veröffentlicht in:GeroScience
Hauptverfasser: Koskimäki, Janne, Polster, Sean P., Li, Yan, Romanos, Sharbel, Srinath, Abhinav, Zhang, Dongdong, Carrión-Penagos, Julián, Lightle, Rhonda, Moore, Thomas, Lyne, Seán B., Stadnik, Agnieszka, Piedad, Kristina, Cao, Ying, Shenkar, Robert, Dimov, Alexey V., Hobson, Nick, Christoforidis, Gregory A., Carroll, Timothy, Girard, Romuald, Awad, Issam A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525636/
https://ncbi.nlm.nih.gov/pubmed/32556941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00201-4
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