Antibodies in Cerebral Cavernous Malformations React with Cytoskeleton Autoantigens in the Lesional Milieu

Previous studies have reported robust inflammatory cell infiltration, synthesis of IgG, B-cell clonal expansion, deposition of immune complexes and complement within cerebral cavernous malformation (CCM) lesions. B-cell depletion has also been shown to reduce the maturation of CCM in murine models....

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Detalhes bibliográficos
Publicado no:J Autoimmun
Main Authors: Zhang, Dongdong, Kinloch, Andrew J., Srinath, Abhinav, Shenkar, Robert, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Koskimäki, Janne, Mohsin, Azam, Carrión-Penagos, Julián, Romanos, Sharbel, Shen, Le, Clark, Marcus R., Shi, Changbin, Awad, Issam A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483292/
https://ncbi.nlm.nih.gov/pubmed/32362501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2020.102469
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