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Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

Brain senescence is associated with impaired endothelial barrier function, angiogenic and inflammatory activity, and propensity to brain hemorrhage. The same pathological changes occur in cerebral cavernous malformations (CCM), a genetic neurovascular anomaly. We hypothesized common transcriptomic a...

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Τόπος έκδοσης:	GeroScience
Κύριοι συγγραφείς:	Koskimäki, Janne, Polster, Sean P., Li, Yan, Romanos, Sharbel, Srinath, Abhinav, Zhang, Dongdong, Carrión-Penagos, Julián, Lightle, Rhonda, Moore, Thomas, Lyne, Seán B., Stadnik, Agnieszka, Piedad, Kristina, Cao, Ying, Shenkar, Robert, Dimov, Alexey V., Hobson, Nick, Christoforidis, Gregory A., Carroll, Timothy, Girard, Romuald, Awad, Issam A.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Springer International Publishing 2020
Θέματα:	Original Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7525636/ https://ncbi.nlm.nih.gov/pubmed/32556941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00201-4
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Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

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