Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation

Brain senescence is associated with impaired endothelial barrier function, angiogenic and inflammatory activity, and propensity to brain hemorrhage. The same pathological changes occur in cerebral cavernous malformations (CCM), a genetic neurovascular anomaly. We hypothesized common transcriptomic a...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Koskimäki, Janne, Polster, Sean P., Li, Yan, Romanos, Sharbel, Srinath, Abhinav, Zhang, Dongdong, Carrión-Penagos, Julián, Lightle, Rhonda, Moore, Thomas, Lyne, Seán B., Stadnik, Agnieszka, Piedad, Kristina, Cao, Ying, Shenkar, Robert, Dimov, Alexey V., Hobson, Nick, Christoforidis, Gregory A., Carroll, Timothy, Girard, Romuald, Awad, Issam A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525636/
https://ncbi.nlm.nih.gov/pubmed/32556941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00201-4
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