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Extracellular Vesicles-Mimetic Encapsulation Improves Oncolytic Viro-Immunotherapy in Tumors With Low Coxsackie and Adenovirus Receptor

The oncolytic adenovirus (Adv) exhibited poor infection efficiency in tumor cells with low coxsackie and adenovirus receptor (CAR) on the cell surface, which limits the therapeutic efficacy of the Adv-mediated cancer gene therapy. In addition, the abundant adenovirus neutralizing antibodies also abr...

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Bibliographic Details
Published in:Front Bioeng Biotechnol
Main Authors: Zhang, Yonghui, Wu, Junyi, Zhang, Hailin, Wei, Jiwu, Wu, Junhua
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7525182/
https://ncbi.nlm.nih.gov/pubmed/33042975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.574007
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