Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BMP receptor type-II (BMPR2) levels and thereby mitig...

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Detalhes bibliográficos
Publicado no:Angiogenesis
Main Authors: Szulcek, Robert, Sanchez-Duffhues, Gonzalo, Rol, Nina, Pan, Xiaoke, Tsonaka, Roula, Dickhoff, Chris, Yung, Lai Ming, Manz, Xue D., Kurakula, Kondababu, Kiełbasa, Szymon M., Mei, Hailiang, Timens, Wim, Yu, Paul B., Bogaard, Harm-Jan, Goumans, Marie-José
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2020
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524846/
https://ncbi.nlm.nih.gov/pubmed/32813135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-020-09741-x
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