Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats

During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases, leading to cognitive impairments and neurodegenerative disorders, such as vascular dementia. The reduced oxygenation, energy supply induced metabolic changes, and insufficient neuroplasticity could be reflected...

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Publicado en:Sci Rep
Main Authors: Tukacs, Vanda, Mittli, Dániel, Györffy, Balázs András, Hunyady-Gulyás, Éva, Hlatky, Dávid, Tóth, Vilmos, Ravasz, Lilla, Medzihradszky, F. Katalin, Nyitrai, Gabriella, Czurkó, András, Juhász, Gábor, Kardos, József, Kékesi, Katalin Adrienna
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524772/
https://ncbi.nlm.nih.gov/pubmed/32994510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72868-w
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