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Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats

During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases, leading to cognitive impairments and neurodegenerative disorders, such as vascular dementia. The reduced oxygenation, energy supply induced metabolic changes, and insufficient neuroplasticity could be reflected...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Tukacs, Vanda, Mittli, Dániel, Györffy, Balázs András, Hunyady-Gulyás, Éva, Hlatky, Dávid, Tóth, Vilmos, Ravasz, Lilla, Medzihradszky, F. Katalin, Nyitrai, Gabriella, Czurkó, András, Juhász, Gábor, Kardos, József, Kékesi, Katalin Adrienna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524772/
https://ncbi.nlm.nih.gov/pubmed/32994510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72868-w
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