Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats

During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases, leading to cognitive impairments and neurodegenerative disorders, such as vascular dementia. The reduced oxygenation, energy supply induced metabolic changes, and insufficient neuroplasticity could be reflected...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Tukacs, Vanda, Mittli, Dániel, Györffy, Balázs András, Hunyady-Gulyás, Éva, Hlatky, Dávid, Tóth, Vilmos, Ravasz, Lilla, Medzihradszky, F. Katalin, Nyitrai, Gabriella, Czurkó, András, Juhász, Gábor, Kardos, József, Kékesi, Katalin Adrienna
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524772/
https://ncbi.nlm.nih.gov/pubmed/32994510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72868-w
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