CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia

Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the disease course, and highly leukemia specific, making them attractive neoantigen targets for immunotherapy. A nonameric peptide der...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Biernacki, Melinda A., Foster, Kimberly A., Woodward, Kyle B., Coon, Michael E., Cummings, Carrie, Cunningham, Tanya M., Dossa, Robson G., Brault, Michelle, Stokke, Jamie, Olsen, Tayla M., Gardner, Kelda, Estey, Elihu, Meshinchi, Soheil, Rongvaux, Anthony, Bleakley, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524498/
https://ncbi.nlm.nih.gov/pubmed/32831296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137723
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