CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia

Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the disease course, and highly leukemia specific, making them attractive neoantigen targets for immunotherapy. A nonameric peptide der...

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Vydáno v:J Clin Invest
Hlavní autoři: Biernacki, Melinda A., Foster, Kimberly A., Woodward, Kyle B., Coon, Michael E., Cummings, Carrie, Cunningham, Tanya M., Dossa, Robson G., Brault, Michelle, Stokke, Jamie, Olsen, Tayla M., Gardner, Kelda, Estey, Elihu, Meshinchi, Soheil, Rongvaux, Anthony, Bleakley, Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524498/
https://ncbi.nlm.nih.gov/pubmed/32831296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137723
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