Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia

BACKGROUND: Idiopathic CD4 lymphopenia (ICL) is defined by persistently low CD4(+) cell counts (<300 cells/μL) in the absence of a causal infection or immune deficiency and can manifest with opportunistic infections. Approximately 30% of ICL patients develop autoimmune disease. The prevalence and...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Perez-Diez, Ainhoa, Wong, Chun-Shu, Liu, Xiangdong, Mystakelis, Harry, Song, Jian, Lu, Yong, Sheikh, Virginia, Bourgeois, Jeffrey S., Lisco, Andrea, Laidlaw, Elizabeth, Cudrici, Cornelia, Zhu, Chengsong, Li, Quan-Zhen, Freeman, Alexandra F., Williamson, Peter R., Anderson, Megan, Roby, Gregg, Tsang, John S., Siegel, Richard, Sereti, Irini
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524466/
https://ncbi.nlm.nih.gov/pubmed/32634122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136254
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