The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

AIMS: Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We investigated a novel...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ESC Heart Fail
Päätekijät: Mustroph, Julian, Drzymalski, Marzena, Baier, Maria, Pabel, Steffen, Biedermann, Alexander, Memmel, Bernadette, Durczok, Melanie, Neef, Stefan, Sag, Can Martin, Floerchinger, Bernhard, Rupprecht, Leopold, Schmid, Christof, Zausig, York, Bégis, Guillaume, Briand, Veronique, Ozoux, Marie‐Laure, Tamarelle, Dorothee, Ballet, Veronique, Janiak, Philip, Beauverger, Philippe, Maier, Lars S., Wagner, Stefan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Original Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524064/
https://ncbi.nlm.nih.gov/pubmed/32691522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12895
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