The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

AIMS: Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We investigated a novel...

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Detalhes bibliográficos
Publicado no:ESC Heart Fail
Main Authors: Mustroph, Julian, Drzymalski, Marzena, Baier, Maria, Pabel, Steffen, Biedermann, Alexander, Memmel, Bernadette, Durczok, Melanie, Neef, Stefan, Sag, Can Martin, Floerchinger, Bernhard, Rupprecht, Leopold, Schmid, Christof, Zausig, York, Bégis, Guillaume, Briand, Veronique, Ozoux, Marie‐Laure, Tamarelle, Dorothee, Ballet, Veronique, Janiak, Philip, Beauverger, Philippe, Maier, Lars S., Wagner, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524064/
https://ncbi.nlm.nih.gov/pubmed/32691522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12895
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