The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

AIMS: Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We investigated a novel...

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Bibliografiske detaljer
Udgivet i:ESC Heart Fail
Main Authors: Mustroph, Julian, Drzymalski, Marzena, Baier, Maria, Pabel, Steffen, Biedermann, Alexander, Memmel, Bernadette, Durczok, Melanie, Neef, Stefan, Sag, Can Martin, Floerchinger, Bernhard, Rupprecht, Leopold, Schmid, Christof, Zausig, York, Bégis, Guillaume, Briand, Veronique, Ozoux, Marie‐Laure, Tamarelle, Dorothee, Ballet, Veronique, Janiak, Philip, Beauverger, Philippe, Maier, Lars S., Wagner, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7524064/
https://ncbi.nlm.nih.gov/pubmed/32691522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12895
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