CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

CRISPR-nucleases have been widely applied for editing cellular and viral genomes, but nuclease-mediated genome editing of double-stranded RNA (dsRNA) viruses has not yet been reported. Here, by engineering CRISPR-Csy4 nuclease to localize to rotavirus viral factories, we achieve the nuclease-mediate...

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Библиографические подробности
Опубликовано в: :Cell Rep
Главные авторы: Papa, Guido, Venditti, Luca, Braga, Luca, Schneider, Edoardo, Giacca, Mauro, Petris, Gianluca, Burrone, Oscar R.
Формат: Artigo
Язык:Inglês
Опубликовано: The Authors. 2020
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523552/
https://ncbi.nlm.nih.gov/pubmed/32997981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108205
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