Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories

Rotavirus (RV) replicates in round-shaped cytoplasmic viral factories, although how they assemble remains unknown. During RV infection, NSP5 undergoes hyperphosphorylation, which is primed by the phosphorylation of a single serine residue. The role of this posttranslational modification in the forma...

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Foilsithe in:J Virol
Main Authors: Papa, Guido, Venditti, Luca, Arnoldi, Francesca, Schraner, Elisabeth M., Potgieter, Christiaan, Borodavka, Alexander, Eichwald, Catherine, Burrone, Oscar R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2019
Ábhair:
Genome Replication and Regulation of Viral Gene Expression
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912106/
https://ncbi.nlm.nih.gov/pubmed/31619556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01110-19
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