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Simultaneous Assessment of Intracellular and Extracellular pH using Hyperpolarized [1-(13)C]Alanine Ethyl Ester

Tissue pH is tightly regulated in vivo, being a sensitive physiological biomarker. Advent of dissolution dynamic nuclear polarization (DNP) and its translation to humans stimulated development of pH-sensitive agents. However, requirements of DNP probes such as biocompatibility, signal sensitivity, a...

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Détails bibliographiques
Publié dans:Anal Chem
Auteurs principaux: Chen, Jun, Hackett, Edward P., Singh, Jaspal, Kovács, Zoltán, Park, Jae Mo
Format: Artigo
Langue:Inglês
Publié: 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522639/
https://ncbi.nlm.nih.gov/pubmed/32786486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01568
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