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Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant
An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu(2+)” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol, hydroquinone, phloroglucinol, o-phenylenediamine, 3,3′,5,...
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| Yayımlandı: | iScience |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7522124/ https://ncbi.nlm.nih.gov/pubmed/33083724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101555 |
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