Characterization of Highly Efficient RNA‐Cleaving DNAzymes that Function at Acidic pH with No Divalent Metal‐Ion Cofactors

Here, we describe the characterization of new RNA‐cleaving DNAzymes that showed the highest catalytic efficiency at pH 4.0 to 4.5, and were completely inactive at pH values higher than 5.0. Importantly, these DNAzymes did not require any divalent metal ion cofactors for catalysis. This clearly sugge...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Kasprowicz, Aleksandra, Stokowa‐Sołtys, Kamila, Jeżowska‐Bojczuk, Małgorzata, Wrzesiński, Jan, Ciesiołka, Jerzy
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288747/
https://ncbi.nlm.nih.gov/pubmed/28168150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201600141
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