Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling

Tractional remodeling of collagen fibrils by fibroblasts requires long cell extensions that mediate fibril alignment. The formation of these cell extensions involves flightless I (FliI), an actin-binding protein that contains a leucine-rich-repeat (LRR), which binds R-ras and may regulate cdc42. We...

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Pubblicato in:Mol Biol Cell
Autori principali: Arora, P. D., Nakajima, K., Nanda, A., Plaha, A., Wilde, A., Sacks, D. B., McCulloch, C. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521798/
https://ncbi.nlm.nih.gov/pubmed/32432944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-10-0554
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