Adaptation induced by self-targeting in a type I-B CRISPR-Cas system

Haloferax volcanii is, to our knowledge, the only prokaryote known to tolerate CRISPR-Cas–mediated damage to its genome in the WT background; the resulting cleavage of the genome is repaired by homologous recombination restoring the WT version. In mutant Haloferax strains with enhanced self-targetin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Stachler, Aris-Edda, Wörtz, Julia, Alkhnbashi, Omer S., Turgeman-Grott, Israela, Smith, Rachel, Allers, Thorsten, Backofen, Rolf, Gophna, Uri, Marchfelder, Anita
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521656/
https://ncbi.nlm.nih.gov/pubmed/32723866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014030
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