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High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon
CRISPR-Cas systems allow bacteria and archaea to acquire sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specific degradation of invader DNA or RNA. However, this involves the risk of autoimmunity if immune memory against host DNA is mistakenly acquired....
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5435918/ https://ncbi.nlm.nih.gov/pubmed/28334774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx150 |
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