Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

Clonal hematopoiesis is associated with various age-related morbidities. Error-corrected sequencing (ECS) of human blood samples, with a limit of detection of ≥0.0001, has demonstrated that nearly every healthy individual >50 years old harbors rare hematopoietic clones below the detection limit o...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Wong, Wing Hing, Bhatt, Sima, Trinkaus, Kathryn, Pusic, Iskra, Elliott, Kevin, Mahajan, Nitin, Wan, Fei, Switzer, Galen E., Confer, Dennis L., DiPersio, John, Pulsipher, Michael A., Shah, Nirali N., Sees, Jennifer, Bystry, Amelia, Blundell, Jamie R., Shaw, Bronwen E., Druley, Todd E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521140/
https://ncbi.nlm.nih.gov/pubmed/31941826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax6249
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