Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

Clonal hematopoiesis is associated with various age-related morbidities. Error-corrected sequencing (ECS) of human blood samples, with a limit of detection of ≥0.0001, has demonstrated that nearly every healthy individual >50 years old harbors rare hematopoietic clones below the detection limit o...

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Publicado en:Sci Transl Med
Main Authors: Wong, Wing Hing, Bhatt, Sima, Trinkaus, Kathryn, Pusic, Iskra, Elliott, Kevin, Mahajan, Nitin, Wan, Fei, Switzer, Galen E., Confer, Dennis L., DiPersio, John, Pulsipher, Michael A., Shah, Nirali N., Sees, Jennifer, Bystry, Amelia, Blundell, Jamie R., Shaw, Bronwen E., Druley, Todd E.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521140/
https://ncbi.nlm.nih.gov/pubmed/31941826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax6249
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