E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases

Malignant melanoma (MM) exhibits a high propensity for central nervous system dissemination with ~50% of metastatic MM patients developing brain metastases (BM). Targeted therapies and immune checkpoint inhibitors have improved overall survival for MM patients with BM. However, responses are usually...

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Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Babiker, Hani M., Byron, Sara A., Hendricks, William P. D., Elmquist, William F., Gampa, Gautham, Vondrak, Jessica, Aldrich, Jessica, Cuyugan, Lori, Adkins, Jonathan, De Luca, Valerie, Tibes, Raoul, Borad, Mitesh J., Marceau, Katie, Myers, Thomas J., Paradiso, Linda J., Liang, Winnie S., Korn, Ronald L., Cridebring, Derek, Von Hoff, Daniel D., Carpten, John D., Craig, David W., Trent, Jeffrey M., Gordon, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519637/
https://ncbi.nlm.nih.gov/pubmed/30264293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0668-8
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