Dynamic PB2-E627K substitution of influenza H7N9 virus indicates the in vivo genetic tuning and rapid host adaptation

Avian-origin influenza viruses overcome the bottleneck of the interspecies barrier and infect humans through the evolution of variants toward more efficient replication in mammals. The dynamic adaptation of the genetic substitutions and the correlation with the virulence of avian-origin influenza vi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Liu, William J., Li, Jun, Zou, Rongrong, Pan, Jingcao, Jin, Tao, Li, Liqiang, Liu, Peipei, Zhao, Yingze, Yu, Xinfen, Wang, Haoqiu, Liu, Guang, Jiang, Hui, Bi, Yuhai, Liu, Lei, Yuen, Kwok-Yung, Liu, Yingxia, Gao, George F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519270/
https://ncbi.nlm.nih.gov/pubmed/32873642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013267117
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