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Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice

A lysine at the 627 position (627K) of PB2 protein of influenza virus has been recognized as a determinant for host adaptation and virulent element for some influenza viruses. While seasonal influenza viruses exclusively contained 627K, the pandemic (H1N1) 2009 possessed a glutamic acid (627E), even...

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Detalhes bibliográficos
Main Authors: Zhu, Huachen, Wang, Jia, Wang, Pui, Song, Wenjun, Zheng, Zuoyi, Chen, Rirong, Guo, Kunyuan, Zhang, Taixing, Peiris, Joseph S.M., Chen, Honglin, Guan, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034467/
https://ncbi.nlm.nih.gov/pubmed/20303563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.02.024
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