Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position

Sequence analyses of influenza PB2 sequences indicate that the 627 position almost exclusively contains either lysine (K) or glutamic acid (E), suggesting a high sequence constraint at this genetic marker. Here, we used a site-directed random mutagenesis method to demonstrate that PB2-627 position h...

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Gepubliceerd in:Virology
Hoofdauteurs: Chin, Alex W.H., Li, Olive T.W., Mok, Chris K.P., Ng, Miko K.W., Peiris, Malik, Poon, Leo L.M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252771/
https://ncbi.nlm.nih.gov/pubmed/25262472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.09.008
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