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Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation

BACKGROUND: Mitochondrial succinate accumulation has been suggested as key event for ischemia reperfusion injury in mice. No specific data are however available on behavior of liver mitochondria during ex situ machine perfusion in clinical transplant models. METHODS: We investigated mitochondrial me...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Schlegel, Andrea, Muller, Xavier, Mueller, Matteo, Stepanova, Anna, Kron, Philipp, de Rougemont, Olivier, Muiesan, Paolo, Clavien, Pierre-Alain, Galkin, Alexander, Meierhofer, David, Dutkowski, Philipp
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519249/
https://ncbi.nlm.nih.gov/pubmed/32979838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103014
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