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Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch
DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7519235/ https://ncbi.nlm.nih.gov/pubmed/32907938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007437117 |
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