Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Gaubitz, Christl, Liu, Xingchen, Magrino, Joseph, Stone, Nicholas P., Landeck, Jacob, Hedglin, Mark, Kelch, Brian A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519235/
https://ncbi.nlm.nih.gov/pubmed/32907938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007437117
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