Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribose transferases and removed by poly(ADP-ribose) glycohydrolase (PARG), which plays important roles in DNA damage repair. While well-studied in somatic tissues, much less is known about poly(ADP-ribosyl)atio...

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Publicat a:Nat Commun
Autors principals: Janisiw, Eva, Raices, Marilina, Balmir, Fabiola, Paulin, Luis F., Baudrimont, Antoine, von Haeseler, Arndt, Yanowitz, Judith L., Jantsch, Verena, Silva, Nicola
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519143/
https://ncbi.nlm.nih.gov/pubmed/32978394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18693-1
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